首页> 外国专利> Compound mixtures based on sulphur containing amino acids, antioxidants, phospholipids and vitamins for the preparation of a medicament for treating L-diabetes and/or associated diseases.

Compound mixtures based on sulphur containing amino acids, antioxidants, phospholipids and vitamins for the preparation of a medicament for treating L-diabetes and/or associated diseases.

机译:基于含硫氨基酸,抗氧化剂,磷脂和维生素的化合物混合物,用于制备治疗L型糖尿病和/或相关疾病的药物。

摘要

A medicament (A) for treating L-diabetes and associated diseases consists of the following partial medicaments: (1) agents for improving sulfur-utilizing conjugation, e.g. N-acetylcysteine; (2) antiradical agents, e.g. vitamin C; (3) agents for supplying phospholipids and their components, e.g. lecithin; (4) agents for supplying fat-soluble vitamins and essential fatty acids, e.g. vitamin A; (5) agents for supplying vitamins and trace elements, e.g. zinc ions; and (6) dexpanthenol as agent for alleviating inflammation and atrophy of the small intestinal mucosa. The use of various materials is claimed for the production of a medicament (A) for the treatment of L-diabetes and associated diseases, where (A) consists of a combination of partial medicaments, themselves consisting of combinations of individual materials strictly oriented towards the patho-physiological concept of L-diabetes. The partial medicaments are: (1) agents for improving sulfur-utilizing conjugation, comprising N-acetylcysteine and/or one or more of glutathione, taurine, L-cystine, L-methionine, L-lysine and S-adenosyl-L-methionine; (2) antiradical agents selected from vitamin C, injectable vitamin E preparations, beta -carotene, alpha -lipoic acid, selenium, manganese, rutoside, hesperidin, silibinin and silymarin; (3) agents for combating insufficient supply of phospholipids and phospholipid components, selected from lecithin and/or one or more of cephalin, phosphatidyl inositol and choline (or its orotate, chloride, citrate and/or hydrogen tartrate); (4) agents for combating insufficient supply of fat-soluble vitamins and essential fatty acids, comprising as many as possible of vitamin A, vitamin D, omega -3 fatty acids and omega -6 fatty acids, optionally together with an extract of Rhizoma Curcumae xanthorrhizae as cholagogue for improving fat resorption; (5) agents for combating loss of vitamins and trace elements as a result of excessive bacterial colonization of the small intestine, comprising as many as possible of zinc ions and injectable vitamin B1, vitamin B2, vitamin B6, vitamin B12 and folic acid preparations; and (6) an agent for alleviating inflammation and atrophy of the small intestinal mucosa comprising dexpanthenol. One of these partial medicaments is optionally omitted. ACTIVITY : Antidiabetic; Neuroprotective; Ophthalmological; Vasotropic; Hepatotropic; Hypotensive. MECHANISM OF ACTION : Sulfur-utilizing conjugation promoter; antiradical; phospholipid source; fat-soluble vitamin and essential fatty acid source; vitamin and trace element source.
机译:治疗L型糖尿病和相关疾病的药物(A)由以下部分药物组成:(1)改善硫利用结合的药物,例如N-乙酰半胱氨酸; (2)抗自由基药,例如维生素C; (3)用于提供磷脂及其成分的试剂,例如。卵磷脂(4)用于提供脂溶性维生素和必需脂肪酸的试剂,例如。维生素A; (5)提供维生素和微量元素的试剂,例如锌离子(6)右泛醇作为减轻小肠粘膜炎症和萎缩的药剂。要求使用各种材料生产用于治疗L型糖尿病和相关疾病的药物(A),其中(A)由部分药物的组合组成,它们本身由严格面向药物的单个材料的组合组成L型糖尿病的病理生理概念。部分药物是:(1)用于改善利用硫的结合的试剂,其包含N-乙酰半胱氨酸和/或谷胱甘肽,牛磺酸,L-胱氨酸,L-蛋氨酸,L-赖氨酸和S-腺苷-L-蛋氨酸中的一种或多种。 ; (2)选自维生素C,可注射的维生素E制剂,β-胡萝卜素,α-硫辛酸,硒,锰,芸苔苷,橙皮苷,水飞蓟宾和水飞蓟素的抗自由基剂; (3)用于对抗磷脂和/或磷脂成分的供应不足的磷脂,所述磷脂和/或磷脂成分选自卵磷脂和/或脑磷脂,磷脂酰肌醇和胆碱中的一种或多种(或其乳清酸盐,氯化物,柠檬酸盐和/或酒石酸氢盐); (4)用于抵抗脂溶性维生素和必需脂肪酸供应不足的试剂,包括尽可能多的维生素A,维生素D,ω-3脂肪酸和ω-6脂肪酸,以及姜黄提取物黄皮用作改善脂肪吸收的胆囊癌; (5)用于防止由于小肠细菌过度定殖而引起的维生素和微量元素损失的试剂,包括尽可能多的锌离子和可注射的维生素B1,维生素B2,维生素B6,维生素B12和叶酸制剂; (6)包含右泛醇的减轻小肠粘膜的炎症和萎缩的药剂。这些局部药物之一可选地被省略。活动:抗糖尿病;具有神经保护作用;眼科变压性肝低血压。作用机理:利用硫的共轭促进剂。反激进磷脂来源脂溶性维生素和必需脂肪酸来源;维生素和微量元素的来源。

著录项

  • 公开/公告号EP1537896B1

    专利类型

  • 公开/公告日2008-04-02

    原文格式PDF

  • 申请/专利权人 LIEBEL FRANZ-PETER DR.;

    申请/专利号EP20040026785

  • 发明设计人 LIEBEL FRANZ-PETER DR.;

    申请日2004-11-11

  • 分类号A61P3/10;A61K31/195;A61K38/06;A61K31/185;A61K31/10;A61K31/7076;A61K31/375;A61K31/355;A61K31/07;A61K31/095;A61K31/685;A61K31/593;A61K31/51;A61K31/525;A61K31/4415;A61K31/714;A61K31/565;

  • 国家 EP

  • 入库时间 2022-08-21 19:58:54

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