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Medicament for the prevention and/or the treatment of ischemic heart and peripheral vascular diseases, tumour development and for wound healing

机译:预防和/或治疗缺血性心脏和周围血管疾病,肿瘤发展和伤口愈合的药物

摘要

The present invention is related to a compound or a pharmaceutical composition thereof for the use of a medicament in the modulation of angiogenesis through the tackling of the intracellular free cholesterol-caveolin1-eNOS-NO pathway. The present invention also provides a method of study, testing, screening and manufacturing of new compounds or compositions which influences the angiogenesis via said pathway with the aim of identifying a compound or composition having possible therapeutic or prophylactic properties upon ischemic heart and peripheral vascular diseases including cerebral diseases, tumour development and wound healing.
机译:本发明涉及一种化合物或其药物组合物,其用于通过克服细胞内游离胆固醇-caveolin1-eNOS-NO途径来调节血管生成的药物。本发明还提供了一种研究,测试,筛选和生产新化合物或组合物的方法,该新化合物或组合物通过所述途径影响血管生成,目的是鉴定对缺血性心脏病和周围血管疾病具有可能的治疗或预防特性的化合物或组合物,包括脑疾病,肿瘤发展和伤口愈合。

著录项

  • 公开/公告号EP1586644A3

    专利类型

  • 公开/公告日2008-06-25

    原文格式PDF

  • 申请/专利权人 UNIVERSITE CATHOLIQUE DE LOUVAIN;

    申请/专利号EP20050012435

  • 发明设计人 BALLIGAND JEAN-LUC;FERON OLIVIER;

    申请日2000-08-09

  • 分类号C12N15/12;A61K38/17;A61K31/40;A61K31/70;G01N33/50;A61P9;A61P35;

  • 国家 EP

  • 入库时间 2022-08-21 19:58:39

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