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EPIMERIZATION METHODOLOGIES FOR RECOVERING STEREO ISOMERS IN HIGH YIELD AND PURITY
EPIMERIZATION METHODOLOGIES FOR RECOVERING STEREO ISOMERS IN HIGH YIELD AND PURITY
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机译:高产和高纯度立体异构体的回收方法学
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摘要
The present invention relates to methods of subjecting a mixture of stereoisomers to epimerization and optionally recrystallization procedures to obtain a desired stereoisomer in high yield and purity. Relying upon solubility differences, the epimerization desirably is carried out in a solvent mixture that extends the epimerization equilibrium in favor of the desired stereoisomer. Recrystallization from a solvent mixture upgrades the purity even more. Purified stereoisomers are useful in many applications such as intermediates in the synthesis of pharmacologically important molecules.
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