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USE OF MIMETICS OF SUPEROXIDE DISMUTASE AND OF REDUCTASE GLUTATHIONE IN THE FORM OF ANTICANCER DRUGS
USE OF MIMETICS OF SUPEROXIDE DISMUTASE AND OF REDUCTASE GLUTATHIONE IN THE FORM OF ANTICANCER DRUGS
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机译:抗氧化剂药物形式的超氧化物歧化酶和还原酶谷胱甘肽的类似物的使用
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摘要
The use of a mimetic (I) of superoxide dismutase and glutathione reductase is claimed in the production of an anticancer medicament. An independent claim is included for a pharmaceutical composition containing (I) together with an antitumor agent (II) capable of inducing production of reactive oxygen oxygen species in cells. ACTIVITY : Cytostatic. In tests in mice with transplanted CT-26 tumors, intraperitoneal injection of mangafodipir (Ia) at 10 mg/kg 3 times per week reduced the tumor volume after 1 month by 54% compared with untreated controls; and if this treatment was commenced 2 hours after a single injection of oxaliplatin at 20 mg/kg the tumor volume after 1 month was by 63% compared with that in mice treated with oxaliplatin only. MECHANISM OF ACTION : Superoxide dismutase mimetic; glutathione reductase mimetic.
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