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Use of superoxide dismutase and reductase glutathione mimetics in the form of anticancer drugs
Use of superoxide dismutase and reductase glutathione mimetics in the form of anticancer drugs
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机译:以抗癌药形式使用超氧化物歧化酶和还原酶谷胱甘肽模拟物
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摘要
The use of a mimetic (I) of superoxide dismutase and glutathione reductase is claimed in the production of an anticancer medicament. An independent claim is included for a pharmaceutical composition containing (I) together with an antitumor agent (II) capable of inducing production of reactive oxygen oxygen species in cells. ACTIVITY : Cytostatic. In tests in mice with transplanted CT-26 tumors, intraperitoneal injection of mangafodipir (Ia) at 10 mg/kg 3 times per week reduced the tumor volume after 1 month by 54% compared with untreated controls; and if this treatment was commenced 2 hours after a single injection of oxaliplatin at 20 mg/kg the tumor volume after 1 month was by 63% compared with that in mice treated with oxaliplatin only. MECHANISM OF ACTION : Superoxide dismutase mimetic; glutathione reductase mimetic.
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