CHEMICALLY CROSS-LINKED HYALURONIC ACID HYDROGEL NANOPARTICLES AND THE METHOD FOR PREPARING THEREOF

摘要

Disclosed herein are chemically crosslinked hyaluronic acid nanoparticles and a method for preparing the same. More specifically, the chemically crosslinked hyaluronic acid nanoparticles are prepared by mixing an oil phase containing a surfactant dissolved therein with a water phase, containing hyaluronic acid and a water-soluble crosslinker, dissolved in an aqueous basic solution, so as to form a w/o emulsion, and crosslinking the hyaluronic acid in the w/o emulsion, are uniformly absorbed and dispersed in the horny layer of the skin when they are applied on the skin, thus showing improved ability to be absorbed into skin, and show high water-swelling ability when they are dispersed in water.