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Method of producing a multichimeric mouse and applications to study the immunopathogenesis of human tissue-specific pathologies
Method of producing a multichimeric mouse and applications to study the immunopathogenesis of human tissue-specific pathologies
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机译:生产多嵌合体小鼠的方法及其在人类组织特异性病理学研究中的应用
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摘要
The invention relates to a method of producing a multichimeric mouse comprising a functional xenogenic (human) immune system restricted to the MHC class I and/or class II molecules (HLA molecules) of the xenogenic species solely, and a functional syngenic tissue. The invention relates also to the use of the multichimeric mouse obtainable by said method, to study the immunopathogenesis of tissue-specific diseases (infectious, tumoral or auto-immune pathologies) and to their applications to design and test vaccines or immunotherapeutic agents against these pathologies.
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