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A BASE FORMING DRUG-LAYERED SILICATE HYBRID CONTAINING BASIC POLYMER AND ITS SYNTHESIS METHOD
A BASE FORMING DRUG-LAYERED SILICATE HYBRID CONTAINING BASIC POLYMER AND ITS SYNTHESIS METHOD
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机译:含碱聚合物的成基成药层状硅酸盐杂化体及其合成方法
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摘要
Provided are a hybrid of a poorly soluble basic drug and a layered silicate, including a water-soluble basic polymer, and a method of preparing the same. The water-soluble basic polymer may be an aminoalkylmethacrylate copolymer (e.g., Eudragit E 100: a copolymer composed of 1: 2:1 ratio of butyl methacrylate, (2,2-dimethylaminoethyl) methacrylate, and methyl methacrylate, Degussa) or polyvinylacetal diethylaminoacetate (AEA). In an oral formulation including the hybrid, a short-term dissolution of the poorly soluble drug can be increased to 90%, thereby increasing drug bioavailability.
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机译:提供了难溶性碱性药物和包括水溶性碱性聚合物的层状硅酸盐的混合物,及其制备方法。水溶性碱性聚合物可以是甲基丙烯酸氨基烷基酯共聚物(例如,Eudragit E 100:由1:1的甲基丙烯酸丁酯,(2,2-二甲基氨基乙基)甲基丙烯酸甲酯和甲基丙烯酸甲酯Degussa组成的共聚物)或聚乙烯醇缩醛二乙基氨基乙酸酯(AEA)。在包括杂化物的口服制剂中,难溶性药物的短期溶出可以增加到90%,从而增加药物的生物利用度。
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