MAKERS FOR THE DIAGNOSIS OF SUSCEPTIBILITY TO LUNG CANCER USING CASPASE-9 GENE AND METHOD FOR PREDICTING AND ANALYZING SUSCEPTIBILITY TO LUNG CANCER USING THE SAME

摘要

Makers for the diagnosis of susceptibility to lung cancer are provided to predict and analyze lung cancer susceptibility by using polymorphisms located at a promoter of a caspase-9(CASP-9) gene closely associated with susceptibility to lung cancer. A marker for the diagnosis of susceptibility to lung cancer is at least one polynucleotide selected from a polynucleotide of SEQ ID NO:1 comprising 20-100 consecutive DNA sequences containing a 242th base(-1263rd base from a transcription-starting point of CASP-9 gene) that is substituted from A to G, a polynucleotide of SEQ ID NO:1 comprising 20-100 consecutive DNA sequences containing a 793rd base(-712nd base from a transcription-starting point of CASP-9 gene) that is substituted from C to T, and a polynucleotide complementary therewith. A method for predicting and analyzing susceptibility to lung cancer comprises the steps of: (a) obtaining a nucleic acid sample from a testing specimen; (b) amplifying at least one polymorphism region selected from a 242nd base of SEQ ID NO:1, a 600th base of SEQ ID NO:1, a 793rd base of SEQ ID NO:1 and 1212nd-1230th bases of SEQ ID NO:1; and (c) determining the base in the amplified polymorphism region.