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Nano?concentrated capsule compositions with high content oil?soluble active materials, it's manufacturing method and cosmetic composition containing the same

机译:具有高含量油溶性活性物质的纳米浓缩胶囊组合物,其制备方法和含有该组合物的化妆品组合物

摘要

The present invention is a technology for easily applying nanotechnology, which has recently been spotlighted in recent years, at low cost and high efficiency, as well as expanding its application scope to basic cosmetics, color cosmetics, and the like, and protects the skin from external substances and loses moisture. To reduce and reduce the concentration of the lipophilic bioactive substance with a composition similar to keratinocytes and intercellular lipids to promote the skin delivery of the drug to the concentration of 30 ~ 80nm, and to apply the cosmetic Injecting an effective amount of the desired lipophilic physiologically active substance into the 80-150nm nanocapsule having a skin-like composition and structure can be easily obtained by simple agitation, thereby allowing transdermal absorption of lipophilic drugs as well as feeling. Excess lipophilic physiological activity that can double the efficacy of drugs The present invention relates to a nano-enriched capsule composition containing vagina and a method for preparing the same, wherein the phospholipid, ceramide, cholesterol, fatty acid and antioxidant are dissolved in a solvent having two or more hydroxyl groups such as butylene glycol, propylene glycol, and glycerin. Make a lipid enrichment part, dissolve and homogenize the lipophilic active material part including the desired lipophilic bioactive material and the suitable emollient oil, and homogenize by dissolving it by adding water and water-soluble antioxidant to it, Treatment with a type emulsifier yields a nanoconcentrated capsule composition having a nanosize of 30 to 80 nm while encapsulating the lipophilic active material in excess, wherein the capsule has an excess between the multi-layer and the bilayer. Encapsulating lipophilic substances in Nanotechnology of the cotton lipophilic active material is characterized by the development of a technology that can reduce the volume of particles without using a high-cost and low-efficiency high-pressure emulsifier.;Enriched, nanoparticles, lipophilic bioactive substances, cell membrane analogues, hydroxyl groups, phospholipids, ceramides, cholesterol
机译:本发明是一种易于应用的纳米技术,近年来以低成本和高效率受到关注,并且将其应用范围扩展到基本化妆品,有色化妆品等,并保护皮肤免受皮肤伤害。外部物质并失去水分。用与角质形成细胞和细胞间脂质相似的成分降低和降低亲脂性生物活性物质的浓度,以促进药物向皮肤的递送至30〜80nm的浓度,并在化妆品中应用有效量的所需亲脂性生理剂通过简单的搅拌,可以容易地获得具有皮肤样组成和结构的80-150nm纳米胶囊中的活性物质,从而允许亲脂性药物的透皮吸收和感觉。可以使药物功效加倍的亲脂性过剩的生理活性本发明涉及一种含有阴道的纳米浓缩胶囊组合物及其制备方法,其中将磷脂,神经酰胺,胆固醇,脂肪酸和抗氧化剂溶解在具有两个或多个羟基,例如丁二醇,丙二醇和甘油。制成脂质富集部分,溶解并均质化包含所需亲脂性生物活性物质和合适的润肤油的亲脂性活性物质部分,并通过向其中添加水和水溶性抗氧化剂使其溶解而均质化,用类型乳化剂处理可产生纳米浓缩物具有30-80nm的纳米尺寸的胶囊组合物,同时包封过量的亲脂活性材料,其中所述胶囊在多层和双层之间具有过量。将亲脂性物质包裹在棉质亲脂性活性物质的纳米技术中,其特征是开发了一种无需使用高成本,低效率的高压乳化剂就可以减少颗粒体积的技术;浓缩的纳米颗粒,亲脂性生物活性物质,细胞膜类似物,羟基,磷脂,神经酰胺,胆固醇

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