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A NOVEL BIODEGRADABLE POLYESTERAMINE BASED ON POLYCAPROLACTONE DIACRYLATE AND POLYETHYLENIMINE AS A GENE CARRIER
A NOVEL BIODEGRADABLE POLYESTERAMINE BASED ON POLYCAPROLACTONE DIACRYLATE AND POLYETHYLENIMINE AS A GENE CARRIER
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机译:聚己内酯双丙烯酸酯和聚乙烯亚胺作为基因载体的新型可生物降解的聚脂胺
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摘要
A novel gene carrier is provided to reduce cytotoxicity and biodegradability, and improve gene deliver efficiency and complex-forming ability with DNA by using biodegradable polyesteramine based on polycaprolactone diacrylate and polyethyleneimine. A method for preparing a novel gene carrier comprises the steps of: independently dissolving polyethyleneimine and polycaprolactone diacrylate in anhydrous methyl alcohol; mixing the dissolved polyethyleneimine and polycaprolactone diacrylate; sealing the mixture with a solvent-resistant cover and reacting them at 40 deg. C for 24 hours; and subjecting the reaction product to dialysis with a membrane of 6,000-8,000 dalton at 4 deg. C for 24 hours. Further, a mol rate of the polycaprolactone diacrylate and the polyethyleneimine is 1:1 to 4.
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