OROTATE AND OROTATE DERIVATIVES OF ENHANCING BIOSYNTHESIS OF HYALURONIC ACID AND/OR GLYCOSAMINOGLYCAN

摘要

An ingredient including orotic acid or its derivative is arranged to the biosynthesis for enhancing hyaluronic acid and/or the glutinous polysaccharide in cartilage cell, synovial cell, myofibroblast, etc., arthritis is prevented or handles, sagging interverbebral disc is chosen, dry eye syndrome, atopic dermatitis, etc.. One ingredient, for enhance hyaluronic acid biosynthesis and/or glutinous polysaccharide, as an active component contain at least one selected from orotic acid and its derived product. Orotic acid derivatives are at least one selected from group comprising sodium, potassium, calcium, magnesium, zinc, manganese, selenium, chromium, lithium, cobalt, iron and ammonium, cholergol, creatine Orotate, carnitine Orotate, arginine Orotate, lysine Orotate, chitosan Orotate, chitosan oligosaccharide Orotate, polylysin Orotate, orotidylate (orotidylic acid), orotidine and dihydrooratic acid Orotate.