Compounds of Formula 1 are useful for the treatment of hyperproliferative skin diseases, tumor diseases, sebaceous gland diseases, and symptoms associated with photodamaged skin:;[Formula 1];In the above formula,;R is hydrogen, fluorine or hydroxy,;R 2 is hydrogen, lower alkyl or halogen,;X is = CH 2 or when R is hydroxy X is (H, H) or = CH 2 ,;A is -C≡C-, Or -CH 2 -CH 2- .
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