GENE RELATED WITH DIFFERENTIATION OF HUMAN STEM CELL LINES

摘要

A method of controlling the gene expression is provided to control the differentiation of stem cell lines by up-regulating identified genes or down-regulating identified genes. To control the gene expression for controlling differentiation of human stem cell lines, a gene selected from the group consisting of RHOG(GenBank Accession No. X61587), HIF1A(GenBank Accession No. AA789181), PPIG(GenBank Accession No. AA954914), BCAT1(GenBank Accession No. AI970531), PLOD2(GenBank Accession No. U84573), PYGL(GenBank Accession No. AI091042), HUMAUANTIG(GenBank Accession No. AA902387), MANBA(GenBank Accession No. U60337), PTPN12(GenBank Accession No. D13380), SDCCAG1 (GenBank Accession No. AA670455), KAB(GenBank Accession No. AB022657), KIAA0372(GenBank Accession No. AB002370), PMAIP1(GenBank Accession No. D90070), ANKRD12(GenBank Accession No. AI692537), PHC3(GenBank Accession No. AA400519), MTHFD2(GenBank Accession No. X16396) and REGL (GenBank Accession No. D56495) is up-regulated or a gene selected from the group consisting of FZD9(GenBank Accession No. U82169), COL4A3(GenBank Accession No. M81379), MUC1(GenBank Accession No. AI922289), MGP(GenBank Accession No. AA484893), TF(GenBank Accession Accession Accession No. NM_016730), CLU(GenBank Accession No. X14723), OLFM1(GenBank Accession No. D82343), UMOD(GenBank Accession No. M15881) and RNASE1 (GenBank Accession No. AL046791) is down-regulated.