F-18-fluorobenzylidenehydrazone-nicotineamide-peptides for peptide receptor imaging agent and an efficient method to label peptides with radioactive fluorine

摘要

A F-18-fluorobenzylidenehydrazone-nicotineamide-peptide compound is provided to be coupled to various peptide receptors existing on various cancerous tissues and angiogenesis portion in human body so as to emit positron, thereby being used as an agent for positron emission tomography. The F-18-fluorobenzylidenehydrazone-nicotineamide-peptide compound is represented by the formula(1) and prepared by mixing a hydrazinonicotinamide-peptide represented by the formula(2) with an F-18-fluorobenzaldehyde represented by the formula(3) so as to form a hydrazone bond.