NANOPARTICLES MADE OF PROTEIN WITH COUPLED APOLIPOPROTEIN E FOR PENETRATION OF THE BLOOD-BRAIN BARRIER AND METHODS FOR THE PRODUCTION THEREOF

摘要

The present invention relates to nanoparticles for penetrating the blood-brain barrier. The nanoparticles are characterized in that they consist of a hydrophile protein or of a combination of hydrophile proteins, preferably of serum albumin, with particular preference of human origin, to which apolipoprotein E is coupled. The invention further relates to processes for the manufacture of such nanoparticles.