The Functionalized Silica Nanoparticle having PEG Linkage and Production Method Thereof

摘要

the present invention, the present invention is polyethylene glycol (PEG) is a combined functional silica nanoparticles and its relates to a manufacturing method and, more particularly, by attaching PEG groups in general nano-particles, highly reactive functional silica by attaching the PEG before combination in addition to the ligand of the cell and prevents the aggregation phenomenon of the nano-particles and nano-particles of manufacturing relates to a method. The invention and the amine group bonded silica nano particles on the surface, the amine functional groups is bonded PEG silica nanoparticles and the silica nanoparticle further folate (folate) is coupled or wherein the folate is coupled to a PEG to provide a functional silica nanoparticles. Further, ) reverse microemulsion method according to a conventional dye-step synthesis of nano-particles; ) comprising the nano-particles surface-treated with an amine group of the ); ) provides a method for producing the functional silica nanoparticles, comprising the step of introducing the PEG to the amine group, the ) after step may include the step of combining folate. ; nanoparticles, aggregation phenomena, reactive, PEG