COMPOSITON FOR TREATING OR PREVENTING AMYLOID-RELATED DISEASES COMPRISING OBOVATOL

摘要

A composition comprising obovatol(4',5-diallyl-2,3-dihydroxybiphenyl ether) is provided to inhibit activity of beta-secretase and gamma-secretase, thereby being useful for treating or preventing a disease related to amyloid such as Alzheimer's disease, Down's syndrome, cognitive disorder, amnesia, and amyloidosis. A pharmaceutical composition for enhancing memory comprises obovatol represented by a formula(1) or a pharmaceutically acceptable salt thereof as an effective ingredient, wherein the obovatol is extracted from Magnolia officinalis Rehd. et Wils..