Process for the preparation of 1- (β-phenyl-ethyl) -4- (p-dimethylaminobenzylideneamino) -1,2,4-triazolium bromide

摘要

1.method u043fu043eu043bu0443u0447u0435u043du0438u00a0 u0431u0440u043eu043cu0438u0434u0430 1 - (- u0444u0435u043du0438u043bu044du0442u0438u043b) - 4 - (n - u0434u0438u043cu0435u0442u0438u043bu0430u043cu0438u043du043eu0431u0435u043du0437u0438u043bu0438u0434u0435u043du0430u043cu0438u043du043e) - 1,2,4 - u0442u0440u0438u0430u0437u043eu043bu0438u00a0 comprising the reaction of 4 - amino - 1,2,4 - u0442u0440u0438u0430u0437u043eu043bu0430 with - u0431u0440u043eu043cu044du0442u0438u043bu0431u0435u043du0437u043eu043bu043eu043c, u043eu0442u043bu0438u0447u0430u044eu0449u0438u0439u0441u00a0 order that 4 - amino - 1,2,4 - u0442u0440u0438u0430u0437u043eu043b u0440u0430u0441u0442u0432u043eu0440u00a0u044eu0442 in u0431u0443u0442u0430u043du043eu043bu0435, then the mixture u0432u043du043eu0441u00a0u0442 solution 3 u0431u0440u043eu043cu044du0442u0438u043bu0431u0435u043du0437u043eu043bu0430 and reaction mixture u043au0438u043fu00a0u0442u00a0u0442 for 6 - 8 hafter u043eu0445u043bu0430u0436u0434u0435u043du0438u00a0 mixtures up to 50 - 60u0441 in her u0432u043du043eu0441u00a0u0442 solutio n - u0434u0438u043cu0435u0442u0438u043bu0430u043cu0438u043du043eu0431u0435u043du0437u0430u043bu044cu0434u0435u0433u0438u0434u0430 in u0431u0443u0442u0430u043du043eu043bu0435 and catalyst are hemorrhaging u0431u0440u043eu043cu0438u0441u0442u043eu0432u043eu0434u043eu0440u043eu0434u043du043e concentrated solution s acid obtained reaction mixture rich in 50 60u0441 for 3 to 5 hours, cooled to room temperature, washed on the filter residue u043eu0442u0444u0438u043bu044cu0442u0440u043eu0432u044bu0432u0430u044eu0442, ether or b u0443u0442u0430u043du043eu043bu043eu043c.;2. method for u043eu0442u043bu0438u0447u0430u044eu0449u0438u0439u0441u00a0 1, so that a reactionary process u043fu0440u043eu0432u043eu0434u00a0u0442 in one stage without u0432u044bu0434u0435u043bu0435u043du0438u00a0 intermediate u0431u0440u043eu043cu0438u0434u0430 1 - (- u0444u0435u043du0438u043bu044du0442u0438u043b) - 4 amino - 1,2,4 u0442u0440u0438u0430u0437u043eu043bu0438u00a0.;3. method for 1 or 2 u043eu0442u043bu0438u0447u0430u0435u0442u0441u00a0 the reaction using 4 - amino - 1,2,4 - u0442u0440u0438u0430u0437u043eu043b, u0431u0440u043eu043cu044du0442u0438u043bu0431u0435u043du0437u043eu043b and n - u0434u0438u043cu0435u0442u0438u043bu0430u043cu0438u043du043eu0431u0435u043du0437u0430u043bu044cu0434u0435u0433u0438u0434 in u044du043au0432u0438u043cu043eu043bu00a0u0440u043du044bu0445 u0441u043eu043eu0442u043du043eu0448u0435u043du0438u00a0u0445 1: 1: 1.