N-ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITOR

摘要

FIELD: organic chemistry, medicine.;SUBSTANCE: invention relates to alkylated (1H-benzimidazol-5-yl)-(-4-substituted phenyl)-amine derivatives, in particular compound of formula and pharmaceutically acceptable salts or solvates thereof, wherein R¹, R², and R⁹, are independently hydrogen, halogen, cyano, nitro, trifluoromethyl, difluoromethoxy, trifluorimethoxy, azido, etc.; R⁷ is optionally substituted C₁-C₁₀-alkyl, C₃-C₁₀-cycloalkyl, etc.; A is-OR³ or NR⁴R³; R⁸ is hydrogen, -Cl, -Br, -F, cyano, nitro, etc.; and meanings of the rest substituents are as defined in specification. Also disclosed is composition for MEK inhibition and uses of benzinidazole compounds.;EFFECT: new compounds with value biological properties.;32 cl, 56 ex