6-ALCOXYPYRIDOPYRIMIDINES AND PHARMACEUTICAL COMPOUND POSSESSING ACTIVITY OF MAP p38 KINASE INHIBITORS

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to the formula I compounds or its pharmaceutically acceptable salt or hydrate where Z means N; X¹ means O or S, R¹ means alkyl containing one to six carbon atoms; R² designates hydrogen or alkyl containing one to six carbon atoms; and R³ designates hydrogen or alkyl containing one to six carbon atoms substituted with the -OR^a group where R^a means alkyl containing one to six carbon atoms; saturated nonaromatic cyclic radical containing 3 to 8 atoms in a cycle where one atom in a cycle is a heteroatom selected from N or O, whereas the rest of the atoms in the cycle are carbon atoms, one or two of these carbon atoms being not necessarily substituted by nitrogen atom with the groups -C(O)(C₁-C₆alcoxy) or -SO₂-C₁C₆alkyl. Invention also relates to pharmaceutical composition.;EFFECT: compounds possess inhibiting activity.;13 cl, 1 tbl, 8 ex