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METHOD OF COMPARATIVE ESTIMATION OF PHYSIOLOGICAL ACTIVITY OF PHARMACEUTICAL SUBSTANCES AND PREPARATIONS ON THEIR BASIS
METHOD OF COMPARATIVE ESTIMATION OF PHYSIOLOGICAL ACTIVITY OF PHARMACEUTICAL SUBSTANCES AND PREPARATIONS ON THEIR BASIS
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机译:药物物质生理活性的比较估计方法及其制备方法
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摘要
FIELD: medicine.;SUBSTANCE: invention refers to pharmacy, namely identification, estimation of quality and safety of original and reproduced medical products. Described comparative estimation of physiological activity of original medical products and reproduced medical products or related preparations implies that by means of EPR spectroscopy and spin probes influence of these products on erythrocyte, lymphocyte and thrombocyte membrane structures released of the same blood sample depending on active component concentration in solution and contact time are examined by comparison of corresponding data obtained within concentration corresponding to maximum therapeutic dose.;EFFECT: method enables comparing of pharmaceutical preparations - originals and generics, or pharmaceutical substances, with various impurity compounds, both within quality assessment and from the point of safety for patients.;3 ex, 3 tbl
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