METHOD OF TREATMENT EFFICIENCY EVALUATION FOR CHRONIC HERPETIC INFECTION

摘要

FIELD: medicine.;SUBSTANCE: method comprises determination of IgG-antibodies level in blood plasma before and after treatment. For this purpose content of specific IgG-antibodies to herpes simplex virus of I and II type in patient's blood is determined before treatment and on 7^th, 14^th, and 21^st days after treatment at the remission stage; also the degree of IgG-antibodies' avidity and level of circulating immune complexes (CIC) is evaluated. If the content of specific IgG-antibodies increases no less than 27% in 7 days after treatment, in 14 days - no less than 33%, and in 21 days - no less than 60% compared to initial level; if degree of specific IgG-antibodies avidity compared to initial level increases no less than 25% in 7 days, in 14 days - no less than 38%, and degree of avidity subsequently increases, or remains constant, or reduces no more than 6% in 21 days compared to previous period (14 days); and if CIC content increases no less than 27% in 7 days compared to initial value, in 14 days - no less than 36%, and content of CIC reduces no more than 23% in 21 days compared to previous period (14 days) in cases with initial content of CIC $ 150 arbitrary units, or content of CIC reduces no more than 37% in 7 days compared to initial value, in 14 days - no more than 43%; in 21 days increases no less than 6% compared to previous period (14 days) in cases with initial content of CIC 150 arbitrary units - then conclusions can be drawn that the treatment was effective and prognosis for clinical course is favourable.;EFFECT: increase of valuation objectivity and opportunity to apply the method for treatment at remission stage.;3 tbl