PYRIMIDINE DERIVATIVES, CHARACTERISED BY ANTIPROLIFERATIVE ACTIVITY, AND PHARMACEUTICAL COMPOSITION

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to new pyrimidine derivatives of formula I and their pharmaceutically acceptable salts, which are selective inhibitors of kinases KDR, FGFR and PDGFR and can be used for treatment of oncological diseases. Compound of formula I corresponds to structural formula , where R¹ is selected from group, including H, COR⁴ and COOCHR⁵OCOR⁴; R² and R³ are independently selected from group, including C_1-6alkyl, C_1-6alkyl, substituted with not more than 4 groups, which are independently selected from group, including -NR⁵R⁶,-R⁵, -OR⁵-phenyl,-phenyl, substituted with not more than 2 groups, which are independently selected from group, including OR⁵ and -C_1-4alkyl and heteroaryl, representing aromatic heterocyclic ring system, which contains not more than two rings and includes from 1 to 3 nitrogen atoms, and heterocyclyl, representing saturated cyclic radical, which includes from 1 to 3 nitrogen atoms; R⁵ and R⁶ are independently selected from group H and C_1-5alkyl. Invention also relates to pharmaceutical compositions, containing said compounds of formula I and intermediate products.;EFFECT: obtaining new pyrimidine derivatives, which can be used for treating oncological diseases.;17 cl, 2 tbl, 27 ex