METHOD OF OBTAINING RECOMBINANT POLYPEPTIIDE-ANTAGONIST OF SOMATOTROPIC HORMONE WITH REDUCED CONTENT OF ISOFORM ADMIXTURES (VERSIONS)

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to biotechnology. Method versions lie in fact that trisulfide isoform is brought into contact with mercaptocompound, either with chelating agent or with metal salt.;EFFECT: obtaining polypeptide product with reduced amount of trisulfide isoform admixtures.;30 cl, 5 dwg, 7 ex