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New nucleic acid useful as immuno-stimulating adjuvant for manufacture of a composition for treatment of cancer diseases e.g. colon carcinomas and infectious diseases e.g. influenza and malaria
New nucleic acid useful as immuno-stimulating adjuvant for manufacture of a composition for treatment of cancer diseases e.g. colon carcinomas and infectious diseases e.g. influenza and malaria
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机译:可用作免疫刺激佐剂的新核酸,用于制备治疗癌症的组合物,例如结肠癌和传染病,例如流感和疟疾
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摘要
Nucleic acid (I) is new. Nucleic acid of formula G lX mG n (I) is new. G = guanosine, uracil or an analog; X = guanosine, uracil, adenosine, thymidine, cytosine or an analog; l = 1-40; m = 3; and n = 1-40. Provided that: (a) when l = 1 than G is guanosine or an analog; (b) when l 1 than at least 50% of the nucleotides are guanosine or an analog; (c) when m = 3 than X is uracil or an analog; (d) when m 3 than X carries at least 3 successive uracils or analogs; (e) when n = 1 than G is guanosine or an analog; (f) when n 1 than at least 50% of the nucleotides are guanosine or an analog. ACTIVITY : Immunostimulant; Antimicrobial; Cytostatic; Virucide; Antimalarial; Respiratory-Gen; Anti-HIV; Antibacterial; Protozoacide; Neuroprotective; Dermatological; Antiinflammatory; Immunosuppressive; Anti-Abortive; Gastrointestinal-Gen; Vulnerary; Gynecological; Osteopathic; Antileprotic; Auditory; Antiarthritic; Ophthalmological; Uropathic; Antitubercular; Tuberculostatic; Antiparasitic; Fungicide; Schistosomacide; Anthelmintic. MECHANISM OF ACTION : None given.
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机译:核酸(I)是新的。式G 1 X mG n(I)的核酸是新的。 G =鸟苷,尿嘧啶或类似物; X =鸟苷,尿嘧啶,腺苷,胸苷,胞嘧啶或类似物; l = 1-40; m> = 3;并且n = 1-40。规定:(a)当l = 1时,G为鸟苷或类似物; (b)当l> 1时,至少50%的核苷酸是鸟苷或类似物; (c)当m = 3时,X是尿嘧啶或类似物; (d)当m> 3比X携带至少3个连续的尿嘧啶或类似物时; (e)当n = 1时,G是鸟苷或类似物; (f)当n> 1时,至少50%的核苷酸是鸟苷或类似物。活动:免疫刺激剂;抗菌;细胞抑制杀病毒剂;抗疟疾;呼吸源抗艾滋病毒;抗菌;原虫;具有神经保护作用;皮肤;消炎(药;免疫抑制反堕胎;胃肠源;伤药;妇科整骨;抗麻风病;听觉抗关节炎眼科尿毒症;抗结核结核病;抗寄生虫;杀菌剂血吸虫病;驱虫药。作用机理:未给出。
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