Biologically active molecules, particularly on the basis of the pna and sirna, process for their cell-specific activation as well as application of a kit for the administration

摘要

The object of the invention was to provide biological active substances which, in vitro as well as in vivo can be inserted in cells and exclusively in the desired target cells inhibit the expression of genes can be controlled, without in the case of other cells of the organism to influence the formation of proteins.According to the invention, the active substances (1) have at least a covalent bond with one or more peptides (2, 3), each of which one or more specific and to the target cells typical enzymes selected contain amino acid sequences. As a result of this binding, which exclusively by the, or said target cells typical enzymes for the biological activation of the active substance is broken open, the molecules in the case of other cells as the target cells biologically inactive.These molecules, for example, be used for influencing the gene expression of preferably the ill and infected organs or cells.