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COMBINATION THERAPY WITH EPOXY-STEROIDAL ALDOSTERONE ANTAGONISTS AND CALCIUM CHANNEL BLOCKS FOR THE TREATMENT OF CONGESTIVE HEART FAILURE
COMBINATION THERAPY WITH EPOXY-STEROIDAL ALDOSTERONE ANTAGONISTS AND CALCIUM CHANNEL BLOCKS FOR THE TREATMENT OF CONGESTIVE HEART FAILURE
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机译:环氧-甾体醛固酮拮抗剂和钙通道阻滞剂联合治疗伴发性心力衰竭
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摘要
A combination therapy comprising a therapeutically-effective amount of an epoxy-steroidal aldosterone receptor antagonist and a therapeutically-effective amount of a calcium channel blocker is described for treatment of circulatory disorders, including cardiovascular disorders such as hypertension, congestive heart failure, cirrhosis and ascites. Preferred calcium channel blockers are those compounds having high potency and bioavailability. Preferred epoxy-steroidal aldosterone receptor antagonists are 2O-spiroxane steroidal compounds characterized by the presence of a 9alpha,11alpha-substituted epoxy moiety. A preferred combination therapy includes the calcium channel blocker verapamil HC1 (Benzenacetonitrile, (±) -alpha[3[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)hydrochloride) and the aldosterone receptor antagonist epoxymexrenone.
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