A process for the in - situ - production of chiral, derived from oxazaborolidinborankomplexen compounds which are used in asymmetric reduction reactions

摘要

The invention relates to a method for the in situ preparation of chiral compounds derived from oxazaborolidine-borane complexes. According to the invention, a metal borohydride, a Lewis base and an inorganic acid ester are brought into contact with one another and, subsequently, an optically-active amino alcohol and, optionally, a halide are added. The compound thus produced is a complex that can be used as a catalyst in asymmetric reduction reactions. The reaction is continued with the addition of the material to be reduced, particularly prochiral etheroximes or ketones, for the synthesis of chiral alcohols or chiral amines.