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Crystal structure of the 2c - methyl - d - erythritol - 2,4 - cyclo diphosphate - synthase
Crystal structure of the 2c - methyl - d - erythritol - 2,4 - cyclo diphosphate - synthase
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机译:2c-甲基-d-赤藓醇-2,4-环二磷酸合酶的晶体结构。
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摘要
This invention discloses the crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase and crystal structures of said synthase with 4-diphosphocytidyl-2C-methyl-D-erythritol, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate, cytidine monophosphate, cytidine diphosphate, cytidine and a combination of cytidine monophosphate and 2C-methyl-D-erythritol 2,4-cyclodiphosphate; with or without zinc. Further, computer-aided methods of identifying inhibitors of said synthase and inhibitors are provided.
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