首页>
外国专利>
MUTANT NON-MENTAL MAMMALS WITH SIGMARE DECEPTOR DEFICIENCY AND APPLICATIONS THEREOF
MUTANT NON-MENTAL MAMMALS WITH SIGMARE DECEPTOR DEFICIENCY AND APPLICATIONS THEREOF
展开▼
机译:具有SIGMARE欺骗子缺陷的突变型非心理哺乳动物及其应用
展开▼
页面导航
摘要
著录项
相似文献
摘要
The genome of the non-human mutant mammal, deficient in an endogenous Sigma receptor, contains a mutation that comprises a disruption in an endogenous Sigma receptor gene, wherein said gene disruption gives rise to a mutant lacking detectable levels of endogenous Sigma receptor. The mutant may be used as a control animal for in vivo tests, as well as a source of cells that can be used in in vitro tests. Mutants deficient in the Sigma-1 receptor can be used as models for in vivo study of disorders of the central nervous system, memory alterations, stress conditions and drug addictions, analgesia processes and neuroprotection. Mutants deficient in the Sigma-2 receptor can be used to study diagnostic or therapeutic tools to fight cancer and/or degenerative processes and/or to design compounds capable of preventing, reducing or alleviating the secondary pathology associated with administration of neuroleptic agents.
展开▼