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ALKYLAMONIUM SALT OF OMEPRAZOL AND ESOMEPRAZOLE
ALKYLAMONIUM SALT OF OMEPRAZOL AND ESOMEPRAZOLE
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机译:奥美拉唑和艾美拉唑的烷基铵盐
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摘要
The present invention relates to new salts of omeprazole and esomeprazole respectively, i.e. salts of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzirnidazole and the (S)-enantiomer thereof. More specifically, the present invention relates to alkylammonium salts of the compounds, formed by a reaction of omeprazole and esomeprazole respectively and an alkylamine with formula NRSUB1/SUBRSUB2/SUBRSUB3/SUB, wherein RSUB1 /SUBis a linear, branched, or cyclic CSUB1/SUB-CSUB12/SUB-alkyl group, and RSUB2 /SUBand RSUB3 /SUBare hydrogen. The present invention also relates to a process for preparing crystalline salts, a pharmaceutical preparation, and a method for treatment of gastric related disorders by administering the compound of the invention.
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