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dominant negative membrane - bound flk - 1 receptor of vascular endothelial cell growth factor vegf.

机译:血管内皮细胞生长因子vegf的显性负性膜结合flk-1受体。

摘要

The present invention relates to the use of ligands for the Flk-1 receptor for the modulation of angiogenesis and vasculogenesis. The invention is based, in part, on the demonstration that Flk-1 tyrosine kinase receptor expression is associated with endothelial cells and the identification of vascular endothelial growth factor (VEGF) as the high affinity ligand of Flk-1. These results indicate a major role for Flk-1 in the signaling system during vasculogenesis and angiogenesis. Engineering of host cells that express Flk-1 and the uses of expressed Flk-1 to evaluate and screen for drugs and analogs of VEGF involved in Flk-1 modulation by either agonist or antagonist activities is described. The invention also relates to the use of Flk-1 ligands, including VEGF agonists and antagonists, in the treatment of disorders, including cancer, by modulating vasculogenesis and angiogenesis.
机译:本发明涉及Flk-1受体的配体在调节血管生成和血管生成中的用途。本发明部分基于以下证明:Flk-1酪氨酸激酶受体表达与内皮细胞有关,并且鉴定血管内皮生长因子(VEGF)为Flk-1的高亲和力配体。这些结果表明Flk-1在血管生成和血管生成过程中在信号系统中的主要作用。描述了表达Flk-1的宿主细胞的工程改造,以及表达的Flk-1用于评估和筛选通过激动剂或拮抗剂活性参与Flk-1调节的VEGF药物和类似物的用途。本发明还涉及Flk-1配体,包括VEGF激动剂和拮抗剂,在通过调节血管生成和血管生成来治疗包括癌症在内的疾病中的用途。

著录项

  • 公开/公告号DE69334201D1

    专利类型

  • 公开/公告日2008-03-13

    原文格式PDF

  • 申请/专利号DE19936034201T

  • 申请日1993-11-15

  • 分类号C12N15/12;G01N33/53;A61K31/235;A61K31/275;A61K31/277;A61K31/38;A61K31/40;A61K31/415;A61K31/42;A61K31/495;A61K31/502;A61K31/505;A61K31/517;A61K31/535;A61K38;A61K38/16;A61K39/395;A61P35;C07C229/60;C07C255/36;C07C255/40;C07C255/41;C07C255/66;C07C317/46;C07C327/44;C07D209/18;C07D239/93;C07D239/94;C07D241/42;C07D241/44;C07D487/04;C07D498/04;C07H21/04;C07K14/71;C07K16/28;C12N5/10;C12N15/09;C12N15/62;C12N15/86;C12P21/02;C12P21/08;C12Q1/68;C12R1/91;G01N33/50;G01N33/567;G01N33/577;G01N33/68;

  • 国家 DE

  • 入库时间 2022-08-21 19:47:35

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