composition containing solid particles immobilized radioisotopes, and their use in brachytherapy

摘要

Radioactive composition for use in the therapy of neoplastic and non-neoplastic diseases by means of the application of radioactive sources in direct contact with the tumor tissues or within the same, and for use as an aid in radio-guided surgery, containing radioisotopes immobilized on biocompatible or bioabsorbable solid particles. The said solid particles are incorporated in a biocompatible and bioabsorbable matrix consisting of a hypotonic gel containing, in water, from 2 to 30% by weight of polyvinylpyvrrolidone and from 0.01 to 2% by weight of agar-agar or agarose. The invention also concerns a radiopharmaceutical kit or a kit for use in radio-guided surgery comprising, as separate components, the single constituents of the above composition.