New 4-azacholest-4-ene N-oxide useful to treat or prevent e.g. necrosis, pathological apoptosis and/or necroptosis, diseases of bones, joints, connective tissue and/or cartilage, muscle disease, skin diseases and cardiovascular disease

摘要

4-Azacholest-4-ene N-oxide (I) and their acid addition salts are new. 4-Azacholest-4-ene N-oxide of formula (I) and their acid addition salts are new. R : alkyl moieties of formulae (Ia)-(If). Independent claims are included for: (1) the preparation of (I); (2) a sulfoxide derivative of formula (II); and (3) preparation of (II) comprising reaction of an alcohol compound of formula (III) with a tosyl halide, in the presence of a base. [Image] [Image] [Image] [Image] ACTIVITY : Apoptotic; Osteopathic; Dermatological; Muscular-Gen; Cardiovascular-Gen; Vasotropic; Antianemic; Respiratory-Gen; Gastrointestinal-Gen; Hepatotropic; Metabolic; Nephrotropic; Virucide; Antibacterial; Antidote; Antiinflammatory; Immunosuppressive; Cytostatic; Ophthalmological; Auditory; Neuroprotective; Cardiant; Vulnerary; Cerebroprotective. MECHANISM OF ACTION : None given.