COMPOSITION AND METHOD FOR ENHANCING PHARMACOLOGICAL ACTIVITY AFTER ORAL AND PARENTERAL ADMINISTRATION OF COMPOSITION COMPRISING POLYPEPTIDE-DRUG SUBSTANCE AND OTHER POORLY ABSORBED ACTIVE INGREDIENT

摘要

PPROBLEM TO BE SOLVED: To provide new pharmaceutical agents and compositions as well as new methods for enhancing the absorption of polypeptide drug substances that normally display little if any absorbability when administered orally, and also to provide new compositions and methods for significantly enhancing the bioavailability and pharmacological efficacy of polypeptide drug substances whether administered orally or parenterally. PSOLUTION: The method includes generating a prodrug by chemically linking a therapeutic polypeptide of general formula: aan (wherein aa is an amino acid; and n is an integer of 2 to 40) to an alkyl or aryl carrier moiety to form a prodrug, and administering the prodrug to mammals excluding humans exhibiting physiological abnormality. PCOPYRIGHT: (C)2010,JPO&INPIT