METHOD FOR INDUCING ANALGESIA COMPRISING ALTERNATIVE ADMINISTRATION OF OPIOID RECEPTOR AGONIST AND OPIOID RECEPTOR LIKE RECEPTOR 1 AGONIST AND IMPLANTABLE INFUSION PUMP

摘要

PPROBLEM TO BE SOLVED: To provide a method of producing analgesia in a mammal. PSOLUTION: The method of producing analgesia in a mammal is provided by alternating intrathecal administration to the mammal of a pharmaceutically effective dose of at least one opioid receptor agonist for a first period of time, followed by intrathecal administration to the mammal of a pharmaceutically effective dose of at least one opioid receptor-like receptor 1 agonist for a second period of time. The intrathecal drug administration of the first and second periods of time may be selected so that at least one opioid receptor agonist and at least one opioid receptor-like receptor 1 agonist retard the generation of tolerance in the mammal. PCOPYRIGHT: (C)2009,JPO&INPIT