AROMATIC RING-MODIFIED siRNA WITH HIGH RNA INTERFERENCE EFFECT

摘要

PROBLEM TO BE SOLVED: To provide a new double-stranded RNA which has high nuclease resistance and intracellular introduction efficiency and can give excellent RNA interference effects.;SOLUTION: An aromatic ring-modified double-stranded RNA is provided, wherein, in an siRNA, an aromatic compound (in particular an aromatic compound which can be intercalated or stacked to the siRNA) is bound to at least one of first to sixth nucleotides from 5' end of a sense strand RNA directly or through a linker.;COPYRIGHT: (C)2009,JPO&INPIT