OSTEOBLAST DIFFERENTIATION FACTOR GENE AND ITS USE

摘要

PPROBLEM TO BE SOLVED: To provide a novel factor for inducing differentiation or promoting maturity of osteoblasts, and to provide a pharmaceutical using the same. PSOLUTION: The pharmaceutical contains (1) a protein which comprises an amino acid sequence represented by sequence 1 or (2) a protein which comprises an amino acid sequence represented by sequence 1 modified by addition, deletion or substitution of one or more amino acids and has an activity of inducing differentiation or promoting maturity of osteoblasts. The osteoblast differentiation factor is useful as an active ingredient of a therapeutic agent etc. for osteoporosis and bone fracture. PCOPYRIGHT: (C)2009,JPO&INPIT