首页> 外国专利> PACLITAXEL SOLID COMPOSITION, PACLITAXEL FINE PARTICLE, PACLITAXEL FINE PARTICLE DISPERSION AND METHOD FOR PRODUCING THEM

PACLITAXEL SOLID COMPOSITION, PACLITAXEL FINE PARTICLE, PACLITAXEL FINE PARTICLE DISPERSION AND METHOD FOR PRODUCING THEM

机译:Paclitaxel固体成分,Paclitaxel细颗粒,Paclitaxel细颗粒分散体及其制备方法

摘要

PROBLEM TO BE SOLVED: To provide a paclitaxel solid composition, paclitaxel fine particles, paclitaxel fine particle dispersion, etc., being improved with stability and safety, and a method for producing them.;SOLUTION: This method for producing the paclitaxel solid composition is provided with that in a dissolving process, the paclitaxel and a dispersion stabilizer are dissolved in a volatile organic solvent in a container 13, in a solid composition-producing process following the dissolving process, the organic solvent contained in the solution is removed by evaporation to obtain the paclitaxel solid composition 1 as a remaining material of the removal of the organic solvent and the paclitaxel solid composition 1 is fixed on the inner wall of the container 13, in a water injection process following the solid composition-forming process, the water 2 is injected into the inside of the container 13, and in a process of fine particle dispersion-forming following the water injection process, a laser beam L radiated from a laser beam source 11 is irradiated to the paclitaxel solid composition 1 fixed on the inner wall of the container 13 for giving light energy to the paclitaxel solid composition 1.;COPYRIGHT: (C)2009,JPO&INPIT
机译:要解决的问题:提供一种紫杉醇固体组合物,紫杉醇细颗粒,紫杉醇细颗粒分散体等,其稳定性和安全性得到改善,并且其制备方法。解决方案:该生产紫杉醇固体组合物的方法是在溶解过程中,将紫杉醇和分散稳定剂溶解在容器13中的挥发性有机溶剂中,在溶解过程之后的固体组合物生产过程中,通过蒸发除去溶液中所含的有机溶剂,从而获得紫杉醇固体组合物1作为去除有机溶剂的剩余材料,并将紫杉醇固体组合物1固定在容器13的内壁上,在固体组合物形成过程之后的注水过程中,水2将水注入容器13的内部,并且在注水步骤之后以细颗粒分散形成的过程sss,从激光束源11发射的激光束L照射到固定在容器13内壁上的紫杉醇固体组合物1上,以向紫杉醇固体组合物1提供光能。版权所有:(C)2009,JPO&INPIT

著录项

  • 公开/公告号JP2009084249A

    专利类型

  • 公开/公告日2009-04-23

    原文格式PDF

  • 申请/专利权人 HAMAMATSU PHOTONICS KK;

    申请/专利号JP20070259094

  • 发明设计人 TAKAGI TOKIO;TATEBE GEN;HIRAMATSU MITSUO;

    申请日2007-10-02

  • 分类号A61K31/337;C07D305/14;A61K47/32;A61K47/30;A61K9/10;A61K9/19;

  • 国家 JP

  • 入库时间 2022-08-21 19:42:44

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