Highly selective O- alkylation process of the amide compound with the copper salt

摘要

There are several reaction points for the alkylation reaction, and there is no production method in which the O-alkylation reaction product is obtained with high selectivity In the case of high selectivity, it is limited to a limited structure. The present invention is capable of selectively performing an O-alkylation reaction by selectively reacting with an alkylation reaction agent having a release group in the presence of a phosphorous compound such as a phosphorous acid, using a monovalent copper compound such as a copper oxide The pyrimidylxy derivative or pyridyxyloxy derivative obtained by this reaction is useful as an intermediate between pesticides or pharmaceuticals.General formula (I)