COMPOSITION AND METHOD FOR PREVENTING RESTENOSIS FOLLOWING REVASCULARIZATION PROCEDURE

摘要

PPROBLEM TO BE SOLVED: To provide a method which reduces or prevents restenosis following invasiveness revascularization procedures, and to provide a composition therefor. PSOLUTION: The method for reducing or preventing the restenosis that occurs following the revascularization procedure, comprises administering to a mammal in need of such treatment a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and an active agent selected from a group consisting of, (a) a selective adenosine ASB2A/SBreceptor agonist, (b) the combination of a selective adenosine ASB1/SBantagonist and either a selective adenosine ASB2A/SBreceptor agonist or a non-selective adenosine agonist, and (c) a selective adenosine ASB1/SBantagonist in order to block the adenosine ASB1/SBreceptor activation by endogenously released adenosine. An surgical procedure is also improved relies on selective stimulation of adenosine ASB2A/SBreceptors. PCOPYRIGHT: (C)2009,JPO&INPIT