Its use for drug discovery and CRAC modulators

摘要

For identifying a bioactive agent capable of modulating CRAC channel activity and store-operated calcium influx, calcium release-activated Ca ⁺² (CRAC) channel (CRACM), for example, the present invention relates to the use of CRACM2 and CRACM1. Furthermore, the present invention relates to the use of recombinant nucleic acid encoding a CRACM. One aspect of the present invention includes a method of modulating the activity of determining the binding to the polypeptide of CRACM candidate bioactive agent, CRACM polypeptides that affect CRAC channels permeable. Furthermore, the present invention relates to methods and compositions for regulating the intracellular expression of a nucleic acid encoding a CRACM.