Anti-FCRN antibodies for the treatment of auto / alloimmune diseases

摘要

Antibodies to heavy chain of human FcRn are provided which function as non- competitive inhibitors of IgG binding to FcRn. The antibodies may be polyclonal, monoclonal, chimeric or humanized, or antigen binding fragments thereof. These antibodies are useful for reducing the concentration of pathogenic IgGs in individuals and therefore used as a therapeutic tool in autoimmune and alloimmune conditions.