MANUFACTURING METHOD OF PHOSPHORUS-CONTAINING amp;alpha;-AMINO ACID, AND PHOSPHORUS-CONTAINING NITRO DERIVATIVE AS PRODUCTION INTERMEDIATE THEREOF

摘要

PROBLEM TO BE SOLVED: To provide a method for inexpensively manufacturing a herbicide, D, L-2-amino-4-(hydroxymethylphosphinyl)-butanoic acid in a good yield without generating a large amount of a by-product such as a salt under a mild reaction condition.;SOLUTION: The manufacturing method of D, L-2-amino-4-(hydroxymethylphosphinyl)-butanoic acid comprises reducing a nitro group of a compound represented by formula (3) [wherein R¹ is an alkyl group or a chloroethyl group; and R² is an alkyl group] to convert it into an amino group followed by deprotection by hydrolysis of a phosphoric ester and a carboxylic ester.;COPYRIGHT: (C)2009,JPO&INPIT