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Synergistic modulation of FLT3 kinase using aminoquinoline and aminoquinazoline kinase modulators
Synergistic modulation of FLT3 kinase using aminoquinoline and aminoquinazoline kinase modulators
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机译:使用氨基喹啉和氨基喹唑啉激酶调节剂协同调节FLT3激酶
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摘要
The invention is directed to a method of inhibiting FLT3 tyrosine kinase activity or expression or reducing FLT3 kinase activity or expression in a cell or a subject comprising the administration of a farnesyl transferase inhibitor and a FLT3 kinase inhibitor selected from aminoquinoline and aminoquinazoline compounds of Formula I': where RSUB1/SUB, RSUB2/SUB, RSUB3/SUB, B, Z, Q, p, q and X are as defined herein. Included within the present invention is both prophylactic and therapeutic methods for treating a subject at risk of (or susceptible to) developing a cell proliferative disorder or a disorder related to FLT3.
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