Regulation of granulosa cell apoptosis

摘要

The present invention relates to a culture medium for an oocyte and/or an embryo, the medium including either or both of (i) GDF-9 or a variant thereof; and (ii) an agent that increases the activity of a GDF-9 dependent signalling pathway in one or more of an oocyte, a cumulus cell associated with an oocyte, and an embryo; and to methods using such culture medium.