The present invention provides a preparation having excellent dissolution property and adsorption efficiency of 2-benzyl-5- (4-chlorophenyl) -6- [4- (methylthio) phenyl] -2H-pyridazin-3-one and a method for producing the same. . The present invention relates to 2-benzyl-5- (4-chlorophenyl) -6- [4- (methylthio) phenyl] -2H-pyridazin-3-one adsorbed on silica having a sulfonic acid group. -5- (4-Chlorophenyl) -6- [4- (methylthio) phenyl] -2H-pyridazin-3-one and silica with sulfonic acid groups, and 2-benzyl-5- (4-chlorophenyl) ) -6- [4- (methylthio) phenyl] -2H-pyridazin-3-one and silica having a sulfonic acid group in the presence of a supercritical fluid or a subcritical fluid; There is provided a method for producing the composite, comprising a step of removing a critical fluid or a subcritical fluid. The present invention can efficiently adsorb compound 1, which is a very poorly water-soluble drug, on silica, and can provide a preparation excellent in the dissolution property of compound 1 adsorbed on the silica.
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