At the time for the fastmelt of the poor solubility medicine the dust and its manufacturing method null poor solubility

摘要

PROBLEM TO BE SOLVED: To obtain the subject powder having good solubility and useful as a gargle through dissolving itself in water, by coating the surface of particles comprising a sparingly soluble medicament and a thickening agent with a dispersant. ;SOLUTION: This powder is obtained by coating the surface of particles comprising (A) a sparingly soluble medicament [pref. allopurinol, 2-(3-cyano-4- isobutoxyphenyl)-4-methyl-5-thiazolecarboxylic acid, salicylic acid, or aspirin] and (B) a thickening agent (pref. sodium polyacrylate, carboxymethylcellulose or the like) in the weight ratio A/B of pref. (1:20) to (1:2) with (C) a dispersant (pref. xylitol, sorbitol or the like) and pref. (D) a dissolving auxiliary (pref. polyvinylpyrrolidone or macrogol). It is preferable that the surface of the particles is filmily coated with a layer comprising the components C and D, or both the components C and D are made to adhere in particulate form to the surface of the above particles.;COPYRIGHT: (C)1999,JPO