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In vivo or in vitro method for detecting amyloid deposits comprising at least one amyloidogenic protein

机译:用于检测包含至少一种淀粉样蛋白的蛋白质的淀粉样沉积物的体内或体外方法

摘要

An amyloid deposit can be detected by administering to a subject or applying to a sample a compound of Formula (I) or Formula (II) or structures 1-45, as described, and then imaging to detect binding of the compound to an amyloid deposit, where the amyloido genie protein of the deposit can be AL, AH, ATTR, Abeta2M, AA, AApoAI, AApoAII, AGeI, ALys, AFib, ACys, ABri, ADan, APrP, ACaI, AlAPP, AANF, APro, AIns, AMed, AKer, A(tbn), and/or ALac.
机译:淀粉样沉积可以通过如下方式检测:对受试者施用式(I)或式(II)的化合物或结构1-45的化合物,或将其施用至样品,然后成像以检测化合物与淀粉样沉积的结合,其中沉积物的淀粉样蛋白基因蛋白可以是AL,AH,ATTR,Abeta2M,AA,AApoAI,AApoAII,AGeI,ALys,AFib,ACys,ABri,ADAn,APrP,ACaI,AlAPP,AAAPP,AANF,APro,AIns,AMed ,AKer,A(tbn)和/或ALac。

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